The most common clinical presentation is of flank pain followed by gross or microscopic hematuria. Grossly, CRCC has a light brown to beige appearance, helping to differentiate CRCC from clear (conventional)cell renal carcinoma which is much more common and has a much worse prognosis.
 
 

Microscopic Pathology:

Microscopically one can see vacuolation of the cytoplasm, some cells displaying a perinuclear halo. One of the other features which you see on this slide is that the cells near the blood vessels are larger in size, and as you move farther away from the blood vessels, they become smaller.